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Molecular Profile PIK3CA Q546K
Therapy Trametinib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA Q546K Advanced Solid Tumor sensitive Trametinib Preclinical Actionable In a preclinical study, Mekinist (trametinib) inhibited survival of transformed cell lines overexpressing PIK3CA Q546K in culture (PMID: 26627007). 26627007
PubMed Id Reference Title Details
(26627007) Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. Full reference...