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| Molecular Profile | KIT N822H |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT N822H | Advanced Solid Tumor | predicted - sensitive | Imatinib | Preclinical - Biochemical | Actionable | In a preclinical study, Gleevec (imatinib) treatment decreased Kit autophosphorylation in cells expressing KIT N822H in culture (PMID: 14645423). | 14645423 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (14645423) | Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. | Full reference... |