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| Molecular Profile | FLT3 V491L |
| Therapy | Gilteritinib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 V491L | acute myeloid leukemia | sensitive | Gilteritinib | Case Reports/Case Series | Actionable | In a clinical case study, Xospata (gilteritinib) treatment resulted in disappearance of peripheral blasts in a patient with acute myeloid leukemia harboring FLT3 V491L, and in a preclinical study, inhibited viability of patient-derived acute myeloid leukemia cells in culture (PMID: 41487332). | 41487332 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (41487332) | Acute Myeloid Leukemia With a Non-Canonical FLT3 V491L Mutation: A Case Report With Ex Vivo FLT3 Inhibitors Sensitivity Testing. | Full reference... |