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Molecular Profile EML4 - ALK ALK K1150dup
Therapy Lorlatinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK K1150dup lung adenocarcinoma predicted - resistant Lorlatinib Case Reports/Case Series Actionable In a clinical case study, ALK K1150dup was identified at the time of progression on Lorbrena (lorlatinib) in a patient with lung adenocarcinoma harboring EML4-ALK (PMID: 42129432). 42129432
PubMed Id Reference Title Details
(42129432) The novel ALK K1150dup mutation mediates resistance to frontline lorlatinib and retains sensitivity to gilteritinib. Full reference...