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| Molecular Profile | EML4 - ALK ALK L1196M ALK D1203N |
| Therapy | NVL-655 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK ALK L1196M ALK D1203N | Advanced Solid Tumor | resistant | NVL-655 | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing ALK D1203N and L1196M in the context of EML4-ALK were resistant to NVL-655 treatment in culture (PMID: 42129432). | 42129432 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (42129432) | The novel ALK K1150dup mutation mediates resistance to frontline lorlatinib and retains sensitivity to gilteritinib. | Full reference... |