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| Molecular Profile | MAP2K1 D67N NRAS G12C PTEN del |
| Therapy | Sotorasib |
| Indication/Tumor Type | T-cell acute lymphoblastic leukemia |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MAP2K1 D67N NRAS G12C PTEN del | T-cell acute lymphoblastic leukemia | no benefit | Sotorasib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Lumakras (sotorasib) treatment resulted in decreased Erk1/2 phosphorylation, but demonstrated only a modest effect on viability in a T-cell acute lymphoblastic leukemia cell line harboring NRAS G12C, MAP2K1 D67N, and PTEN deletion in culture, and inhibited Erk1/2 phosphorylation levels in liver-infiltrating cancer cells but did not prolong survival in a cell line xenograft model (PMID: 41340466). | 41340466 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (41340466) | Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer. | Full reference... |