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| Molecular Profile | HRAS G12C |
| Therapy | RMC-6291 |
| Indication/Tumor Type | head and neck carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12C | head and neck carcinoma | sensitive | RMC-6291 | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with RMC-6291 inhibited Erk1/2 phosphorylation and viability in a head and neck carcinoma cell line harboring HRAS G12C in culture (PMID: 41340466). | 41340466 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (41340466) | Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer. | Full reference... |