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| Molecular Profile | JAK2 S755R JAK2 R938Q |
| Therapy | Ruxolitinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to Jakafi (ruxolitinib) in culture (PMID: 24398328). | 24398328 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24398328) | Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors. | Full reference... |