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| Molecular Profile | KIT H697Y |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT H697Y | Advanced Solid Tumor | decreased response | Imatinib | Preclinical | Actionable | In a preclinical study, transformed cell lines overexpressing KIT H697Y demonstrated reduced sensitivity to Gleevec (imatinib mesylate)-induced growth inhibition in culture (PMID: 19861435). | 19861435 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (19861435) | Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas. | Full reference... |