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Molecular Profile BRAF V600E
Therapy Afatinib + Encorafenib
Indication/Tumor Type colorectal cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colorectal cancer sensitive Afatinib + Encorafenib Preclinical - Cell culture Actionable In a preclinical study, Gilotrif (afatinib) and Braftovi (encorafenib) combination treatment suppressed Egfr, Mek, and Erk activation more efficiently than either agent alone, and synergistically inhibited viability and colony formation in cell lines derived from the peritoneal lavage of a microsatellite stable (MSS) colorectal cancer mouse model harboring BRAF V600E along with TP53 R172H (corresponding to R175H in human) and APC loss in culture (PMID: 41566838). 41566838
PubMed Id Reference Title Details
(41566838) Novel Syngeneic Cell Lines for Studying High-Risk BRAFV600E-Driven Colorectal Cancer In Vivo. Full reference...