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| Molecular Profile | BRAF V600E |
| Therapy | Exarafenib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colorectal cancer | sensitive | Exarafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Exarafenib (KIN-2787) inhibited Mek and Erk phosphorylation and suppressed colony formation in cell lines derived from the peritoneal lavage of a microsatellite stable (MSS) colorectal cancer mouse model harboring BRAF V600E along with TP53 R172H (corresponding to R175H in human) and APC loss in culture (PMID: 41566838). | 41566838 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (41566838) | Novel Syngeneic Cell Lines for Studying High-Risk BRAFV600E-Driven Colorectal Cancer In Vivo. | Full reference... |