Profile Response Detail

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Molecular Profile BRAF V600E
Therapy Osimertinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E lung adenocarcinoma predicted - resistant Osimertinib Case Reports/Case Series Actionable In a clinical case study, acquisition of BRAF V600E and loss of EGFR G719A and EGFR S768I were identified in the post-progression biopsy of a patient with metastatic lung adenocarcinoma treated with Tagrisso (osimertinib) (PMID: 42398475). 42398475
PubMed Id Reference Title Details
(42398475) Clonal divergence with acquired BRAF V600E in NSCLC with compound EGFR G719X/S768I after prolonged EGFR-TKI therapy. Full reference...