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| Molecular Profile | ALK R1275L |
| Therapy | Lorlatinib |
| Indication/Tumor Type | neuroblastoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK R1275L | neuroblastoma | predicted - sensitive | Lorlatinib | Case Reports/Case Series | Actionable | In a clinical case study, Lorbrena (lorlatinib) treatment resulted in a partial response with a time to treatment failure of 10.3 months in a patient with neuroblastoma harboring ALK R1275L (reported as ALK c.3824G>T) (PMID: 42150148). | 42150148 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (42150148) | Use of ALK Inhibitors in Patients With Nonlung Malignancies Bearing ALK Alteration Prolongs Treatment Duration. | Full reference... |