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Molecular Profile FLT3 exon 14 ins
Therapy Nintedanib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins acute myeloid leukemia sensitive Nintedanib Preclinical - Cell culture Actionable In a preclinical study, Ofev (nintedanib) inhibited autophosphorylation and downstream signaling, induced cell cycle arrest and apoptosis and inhibited viability in acute myeloid cell lines harboring FLT3-ITD in culture (PMID: 42035942). 42035942
PubMed Id Reference Title Details
(42035942) Nintedanib is a potent FLT3 inhibitor with activity against FLT3-ITD and overcomes the gatekeeper F691L resistance mutation in acute myeloid leukemia. Full reference...