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Molecular Profile MAP2K1 K57N
Therapy Panitumumab
Indication/Tumor Type colorectal cancer
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57N colorectal cancer resistant Panitumumab Preclinical Actionable In a preclinical study, colorectal cancer cell lines expressing MAP2K1 K57N were insensitive to Vectibix (panitumumab) in culture (PMID: 26644315). 26644315
MAP2K1 K57N colorectal cancer resistant Panitumumab Case Reports/Case Series Actionable In a retrospective analysis, two patients with metastatic RAS/BRAF wild-type colorectal cancer demonstrated progressive disease following treatment with Vectibix (panitumumab) and via analysis of archived pretreatment tumor biopsy samples and post-progression liquid biopsy both were found to harbor MAP2K1 K57N (PMID: 36419886). 36419886
PubMed Id Reference Title Details
(26644315) Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer. Full reference...
(36419886) Case Report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer. Full reference...