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Molecular Profile | MAP2K1 K57T |
Therapy | Panitumumab + Trametinib |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MAP2K1 K57T | colorectal cancer | sensitive | Panitumumab + Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, a combination of Vectibix (panitumumab) and Mekinist (trametinib) caused tumor regression in a patient’s colorectal cancer metastases harboring MAP2K1 K57T after being identified pre-clinically as a combination likely to inhibit MAP2K1 K57T expressing colorectal cancer (PMID: 26644315). | 26644315 |
PubMed Id | Reference Title | Details |
---|---|---|
(26644315) | Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer. | Full reference... |