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Molecular Profile | PTEN dec exp |
Therapy | Nivolumab |
Indication/Tumor Type | melanoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN dec exp | melanoma | decreased response | Nivolumab | Clinical Study - Cohort | Actionable | In a clinical study, melanoma patients with PTEN expression in less than 10% of tumor cells demonstrated decreased response to anti-PD-1 antibodies, including Opdivo (nivolumab), as compared to patients in which PTEN is present in over 10% of tumor cells (PMID: 26645196). | 26645196 |
PubMed Id | Reference Title | Details |
---|---|---|
(26645196) | Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. | Full reference... |