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Molecular Profile | BRAF mut PTEN loss |
Therapy | GSK2636771 |
Indication/Tumor Type | melanoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF mut PTEN loss | melanoma | no benefit | GSK2636771 | Preclinical | Actionable | In a preclinical study, GSK2636771 resulted in no benefit in a melanoma mouse model co-harboring a BRAF mutation and PTEN loss (PMID: 26645196). | 26645196 |
PubMed Id | Reference Title | Details |
---|---|---|
(26645196) | Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. | Full reference... |