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Molecular Profile | BRAF V600E |
Therapy | Navitoclax + Vemurafenib |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | colon cancer | sensitive | Navitoclax + Vemurafenib | Preclinical | Actionable | In a preclinical study, Navitoclax (ABT-263) enhanced the inhibitory effect of Zelboraf (vemurafenib) on human colon cancer cells harboring BRAF V600E in culture (PMID: 25665005). | 25665005 |
PubMed Id | Reference Title | Details |
---|---|---|
(25665005) | The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. | Full reference... |