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Molecular Profile | BRAF V600E |
Therapy | Trametinib + TW-37 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | melanoma | sensitive | Trametinib + TW-37 | Preclinical | Actionable | In a preclinical study, TW-37 enhanced the inhibitory effect of Mekinist (trametinib) on human melanoma cells harboring BRAF V600E in culture (PMID: 25665005). | 25665005 |
PubMed Id | Reference Title | Details |
---|---|---|
(25665005) | The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. | Full reference... |