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| Molecular Profile | TP53 mutant |
| Therapy | CEP-8983 + Cisplatin |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | lung non-small cell carcinoma | sensitive | CEP-8983 + Cisplatin | Preclinical | Actionable | In a preclinical study, the combination of CEP-8983 and Platinol (cisplatin) worked synergistically to induce cell death in non-small cell lung cancer cell lines in culture, irrespective of TP53 status (PMID: 23428903). | 23428903 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23428903) | Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. | Full reference... |