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| Molecular Profile | JAK2 V617F |
| Therapy | AZD1208 + Ruxolitinib |
| Indication/Tumor Type | bone marrow cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F | bone marrow cancer | sensitive | AZD1208 + Ruxolitinib | Preclinical | Actionable | In a preclinical study, Jakafi (ruxolitinib) worked synergistically with AZD1208 to inhibit proliferation of myeloproliferative cancer cell lines harboring JAK2 V617F in culture (PMID: 26472029). | 26472029 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26472029) | The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells. | Full reference... |