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Molecular Profile | TP53 loss |
Therapy | CPUY201112 |
Indication/Tumor Type | osteosarcoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | osteosarcoma | decreased response | CPUY201112 | Preclinical | Actionable | In a preclinical study, an osteosarcoma cell line lacking TP53 demonstrated a decreased response to CPUY201112 in culture, when compared to osteosarcoma cells with wild-type TP53 (PMID: 26743233). | 26743233 |
PubMed Id | Reference Title | Details |
---|---|---|
(26743233) | CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. | Full reference... |