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Molecular Profile | CSF3R T640N |
Therapy | Ruxolitinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R T640N | Advanced Solid Tumor | sensitive | Ruxolitinib | Preclinical | Actionable | In a preclinical study, Jakafi (ruxolitinib) reduces colony formation of cells expressing CSF3R T640N in culture (PMID: 26475333). | 26475333 |
PubMed Id | Reference Title | Details |
---|---|---|
(26475333) | The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I. | Full reference... |