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| Molecular Profile | ALK R1275Q |
| Therapy | Crizotinib + Cyclophosphamide + Topotecan |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK R1275Q | neuroblastoma | sensitive | Crizotinib + Cyclophosphamide + Topotecan | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Xalkori (crizotinib), Topotecan, and Cytoxan (cyclophosphamide) synergized to sustain tumor regression in human neuroblastoma cell line xenograft models harboring ALK R1275Q and wild-type TP53 (PMID: 26438783). | 26438783 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26438783) | Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma. | Full reference... |