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| Molecular Profile | ALK F1245C TP53 wild-type |
| Therapy | Crizotinib + Cyclophosphamide + Topotecan |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK F1245C TP53 wild-type | neuroblastoma | sensitive | Crizotinib + Cyclophosphamide + Topotecan | Preclinical - Pdx | Actionable | In a preclinical study, Xalkori (crizotinib) worked synergistically with Topotecan and Cytoxan (cyclophosphamide), resulting in sustained tumor regression in crizotinib-resistant neuroblastoma PDX models harboring ALK F1245C and wild-type Tp53 (PMID: 26438783). | 26438783 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26438783) | Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma. | Full reference... |