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| Molecular Profile | PTEN loss |
| Therapy | KU-55933 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | colon cancer | sensitive | KU-55933 | Preclinical | Actionable | In a preclinical study, KU-55933 induced cell cycle arrest and caspase activation in PTEN deficient human colon cancer cells in culture (PMID: 25870146). | 25870146 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25870146) | Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. | Full reference... |