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Molecular Profile | PTEN loss |
Therapy | KU-55933 |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | colon cancer | sensitive | KU-55933 | Preclinical | Actionable | In a preclinical study, KU-55933 induced cell cycle arrest and caspase activation in PTEN deficient human colon cancer cells in culture (PMID: 25870146). | 25870146 |
PubMed Id | Reference Title | Details |
---|---|---|
(25870146) | Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. | Full reference... |