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Molecular Profile | PIK3CA mutant |
Therapy | VS-5584 |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | breast cancer | sensitive | VS-5584 | Preclinical | Actionable | In a preclinical study, PIK3CA mutant breast cancer cells showed increased sensitivity to VS-5584 compared to PIK3CA wild-type cells in culture (PMID: 23270925). | 23270925 |
PubMed Id | Reference Title | Details |
---|---|---|
(23270925) | VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | Full reference... |