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| Molecular Profile | TP53 mutant |
| Therapy | Pazopanib |
| Indication/Tumor Type | sarcoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | sarcoma | sensitive | Pazopanib | Clinical Study - Cohort | Actionable | In a retrospective analysis, advanced sarcoma patients with TP53 mutations displayed improved progression-free survival (208 vs 136 days, p=0.036) relative to patients with wild-type TP53 when treated with Votrient (pazopanib) (PMID: 26646755). | 26646755 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26646755) | TP53 mutational status is predictive of pazopanib response in advanced sarcomas. | Full reference... |