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Molecular Profile | PTEN mutant |
Therapy | TGX-221 |
Indication/Tumor Type | endometrial cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN mutant | endometrial cancer | resistant | TGX-221 | Preclinical | Actionable | In a preclinical study, endometrioid endometrial cancer cell lines harboring PTEN mutations demonstrated resistance to TGX-221 induced growth inhibition in culture (PMID: 23674493). | 23674493 |
PubMed Id | Reference Title | Details |
---|---|---|
(23674493) | PI3K pathway dependencies in endometrioid endometrial cancer cell lines. | Full reference... |