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| Molecular Profile | PTEN mutant |
| Therapy | A66 + AZD6482 |
| Indication/Tumor Type | endometrial cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN mutant | endometrial cancer | sensitive | A66 + AZD6482 | Preclinical | Actionable | In a preclinical study, A66 and AZD6482 combination treatment inhibited viability of endometrioid endometrial cancer cell lines harboring PTEN mutations in culture (PMID: 23674493). | 23674493 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23674493) | PI3K pathway dependencies in endometrioid endometrial cancer cell lines. | Full reference... |