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Molecular Profile | TP53 R248Q |
Therapy | Ganetespib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R248Q | Advanced Solid Tumor | sensitive | Ganetespib | Preclinical | Actionable | In a preclinical study, Ganetespib extended survival by 48% in mice with tumors expressing TP53 R248Q (PMID: 26009011). | 26009011 |
PubMed Id | Reference Title | Details |
---|---|---|
(26009011) | Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. | Full reference... |