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| Molecular Profile | TP53 L194F |
| Therapy | Ganetespib |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 L194F | breast cancer | sensitive | Ganetespib | Preclinical - Cell culture | Actionable | In a preclinical study, Ganetespib inhibited growth of human breast cancer cells harboring TP53 L194F in culture (PMID: 26009011). | 26009011 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26009011) | Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. | Full reference... |