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Molecular Profile | TP53 R175H |
Therapy | Ganetespib |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R175H | breast cancer | sensitive | Ganetespib | Preclinical - Cell culture | Actionable | In a preclinical study, Ganetespib inhibited growth of human breast cancer cells harboring TP53 R175H in culture (PMID: 26009011). | 26009011 |
PubMed Id | Reference Title | Details |
---|---|---|
(26009011) | Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. | Full reference... |