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| Molecular Profile | TP53 P223L TP53 V274F |
| Therapy | Ganetespib |
| Indication/Tumor Type | prostate cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 P223L TP53 V274F | prostate cancer | resistant | Ganetespib | Preclinical | Actionable | In a preclinical study, Ganetespib inhibited growth of human prostate cancer cells harboring TP53 P223L and V274F in culture (PMID: 26009011). | 26009011 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26009011) | Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. | Full reference... |