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Molecular Profile | TP53 mutant |
Therapy | RG7112 |
Indication/Tumor Type | leukemia |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 mutant | leukemia | decreased response | RG7112 | Phase I | Actionable | In a Phase I clinical trial, the majority of 19 leukemia patients with identified TP53 mutations did not demonstrate response to treatment with RG7112, with 2 acute myeloid leukemia patients harboring TP53 mutations showing clinical activity, but not improvement, and 1 sCLL/CLL patient achieving stable disease (PMID: 26459177). | 26459177 |
PubMed Id | Reference Title | Details |
---|---|---|
(26459177) | Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia. | Full reference... |