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Molecular Profile | RET C634W |
Therapy | XMD15-44 |
Indication/Tumor Type | medullary thyroid carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | medullary thyroid carcinoma | sensitive | XMD15-44 | Preclinical | Actionable | In a preclinical study, XMD15-44 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET C634W in culture (PMID: 26046350). | 26046350 |
PubMed Id | Reference Title | Details |
---|---|---|
(26046350) | Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. | Full reference... |