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| Molecular Profile | RET M918T |
| Therapy | XMD15-44 |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET M918T | medullary thyroid carcinoma | sensitive | XMD15-44 | Preclinical | Actionable | In a preclinical study, XMD15-44 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET M918T in culture (PMID: 26046350). | 26046350 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26046350) | Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. | Full reference... |