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Molecular Profile RET M918T
Therapy ALW-II-41-27
Indication/Tumor Type medullary thyroid carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T medullary thyroid carcinoma sensitive ALW-II-41-27 Preclinical - Cell culture Actionable In a preclinical study, ALW-II-41-27 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thryoid carcinoma cells harboring RET M918T in culture (PMID: 26046350). 26046350
PubMed Id Reference Title Details
(26046350) Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. Full reference...