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Molecular Profile | RET M918T |
Therapy | ALW-II-41-27 |
Indication/Tumor Type | medullary thyroid carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET M918T | medullary thyroid carcinoma | sensitive | ALW-II-41-27 | Preclinical - Cell culture | Actionable | In a preclinical study, ALW-II-41-27 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thryoid carcinoma cells harboring RET M918T in culture (PMID: 26046350). | 26046350 |
PubMed Id | Reference Title | Details |
---|---|---|
(26046350) | Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. | Full reference... |