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| Molecular Profile | HRAS G12V |
| Therapy | SF1126 |
| Indication/Tumor Type | high grade glioma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12V | high grade glioma | sensitive | SF1126 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SF1126 inhibited Akt activation, proliferation, and migration of transgenic mouse glioma cells expressing HRAS G12V in culture, and suppressed tumor growth in xenograft models (PMID: 25425962). | 25425962 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25425962) | Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model. | Full reference... |