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Molecular Profile | ALK wild-type |
Therapy | Dalantercept + Doxorubicin |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK wild-type | melanoma | sensitive | Dalantercept + Doxorubicin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Dalantercept (ACE-041) in combination with Adria (doxorubicin) resulted in decreased tumor growth in cell line xenograft models of melanoma, with increased efficacy over either agent alone (PMID: 26373572). | 26373572 |
PubMed Id | Reference Title | Details |
---|---|---|
(26373572) | Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors. | Full reference... |