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Molecular Profile | ATR positive |
Therapy | Berzosertib + Cisplatin |
Indication/Tumor Type | lung cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATR positive | lung cancer | sensitive | Berzosertib + Cisplatin | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Berzosertib (VX-970) sensitized patient-derived lung cancer cells to Platinol (cisplatin) in culture and in patient-derived xenograft (PDX) models (PMID: 25010037). | 25010037 |
PubMed Id | Reference Title | Details |
---|---|---|
(25010037) | Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970. | Full reference... |