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Molecular Profile | IDH1 R132H |
Therapy | AGI-5198 + Radiotherapy |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | colorectal cancer | resistant | AGI-5198 + Radiotherapy | Preclinical | Actionable | In a preclinical study, colorectal cancer cells expressing IDH1 R132H were resistant to radiotherapy when treated with AGI-5198 (PMID: 26363012). | 26363012 |
PubMed Id | Reference Title | Details |
---|---|---|
(26363012) | Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. | Full reference... |