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Molecular Profile | TP53 loss |
Therapy | CTX-1 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | Advanced Solid Tumor | decreased response | CTX-1 | Preclinical | Actionable | In a preclinical study, CTX-1 induced cell death in TP53-deficient human tumor cell lines in culture, but had a greater effect on cell lines with wild-type TP53 compared to isogenic cell lines with TP53 loss (PMID: 26883273). | 26883273 |
PubMed Id | Reference Title | Details |
---|---|---|
(26883273) | Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. | Full reference... |