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| Molecular Profile | TP53 mutant |
| Therapy | CTX-1 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | Advanced Solid Tumor | sensitive | CTX-1 | Preclinical | Actionable | In a preclinical study, CTX-1 induced increased Tp53 protein levels and cell death in human tumor cell lines with mutant Tp53 in culture (PMID: 26883273). | 26883273 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26883273) | Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. | Full reference... |