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| Molecular Profile | TP53 wild-type |
| Therapy | CTX-1 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 wild-type | acute myeloid leukemia | sensitive | CTX-1 | Preclinical | Actionable | In a preclinical study, CTX-1 improved survival time in mouse models of acute myeloid leukemia using TP53 wild-type primary human acute myeloid leukemia cells (PMID: 26883273). | 26883273 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26883273) | Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. | Full reference... |