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Molecular Profile | TP53 wild-type |
Therapy | CTX-1 + Nutlin-3a |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | acute myeloid leukemia | sensitive | CTX-1 + Nutlin-3a | Preclinical | Actionable | In a preclinical study, the combination of CTX-1 and Nutlin-3 resulting in improved survival time in mouse models of acute myeloid leukemia using TP53 wild-type primary human acute myeloid leukemia cells (PMID: 26883273). | 26883273 |
PubMed Id | Reference Title | Details |
---|---|---|
(26883273) | Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. | Full reference... |