Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | TP53 wild-type |
Therapy | CTX-1 + Nutlin-3a |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | Advanced Solid Tumor | sensitive | CTX-1 + Nutlin-3a | Preclinical | Actionable | In a preclinical study, CTX-1 and Nutlin-3 worked cooperatively to induce cell death in several TP53 wild-type human tumor cell lines in culture (PMID: 26883273). | 26883273 |
PubMed Id | Reference Title | Details |
---|---|---|
(26883273) | Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. | Full reference... |