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Molecular Profile TP53 wild-type
Therapy CTX-1 + Nutlin-3a
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type Advanced Solid Tumor sensitive CTX-1 + Nutlin-3a Preclinical Actionable In a preclinical study, CTX-1 and Nutlin-3 worked cooperatively to induce cell death in several TP53 wild-type human tumor cell lines in culture (PMID: 26883273). 26883273
PubMed Id Reference Title Details
(26883273) Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. Full reference...