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Molecular Profile | JAK2 R867Q |
Therapy | Luminespib |
Indication/Tumor Type | hematologic cancer |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 R867Q | hematologic cancer | decreased response | Luminespib | Preclinical | Actionable | In a preclinical study, immune cells expressing JAK2 R867Q demonstrated decreased response to Luminespib (AUY922) in culture (PMID: 24398328). | 24398328 |
PubMed Id | Reference Title | Details |
---|---|---|
(24398328) | Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors. | Full reference... |