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| Molecular Profile | STK11 loss |
| Therapy | unspecified PD-1 antibody |
| Indication/Tumor Type | lung cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| STK11 loss | lung cancer | resistant | unspecified PD-1 antibody | Preclinical | Actionable | In a preclinical study, PD-1 antibodies were ineffective in treating Stk11 (also known as Lkb1) deficient lung tumors in mice (PMID: 26833127). | 26833127 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26833127) | STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment. | Full reference... |